Hypoxia-inducible factor-1: Regulatory mechanisms and drug therapy in myocardial infarction

Jinyuan Pan1, Lei Zhang2, Dongxiao Li3

  • 1Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.

PubMed

Insights

Hypoxia-inducible factor-1 (HIF-1) is vital in myocardial infarction (MI) by regulating cellular responses. Targeting HIF-1 offers potential for novel MI treatments, moving beyond current limited drug options.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Cellular Physiology

Background:

  • Myocardial infarction (MI) is a leading cause of death due to coronary artery blockage and myocardial necrosis.
  • Cellular responses to MI are complex, involving multiple pathological mechanisms.
  • Hypoxia-inducible factor-1 (HIF-1) is a key regulator of cellular behavior under hypoxic conditions.

Purpose of the Study:

  • To summarize HIF-1's regulatory role in cellular responses post-MI.
  • To elucidate the diverse mechanisms of HIF-1 action in MI.
  • To identify potential HIF-1 targeting drugs for MI treatment.

Main Methods:

  • Literature review of studies on HIF-1 and myocardial infarction.
  • Analysis of HIF-1's modulation of cardiomyocytes, endothelial cells, macrophages, and fibroblasts.
  • Review of therapeutic strategies targeting HIF-1.

Main Results:

  • HIF-1 modulates angiogenesis, energy metabolism, oxidative stress, inflammation, and ventricular remodeling post-MI.
  • Current drugs targeting HIF-1 for MI are limited, primarily natural compounds.
  • Precision-targeted drugs modulating HIF-1 show therapeutic potential.

Conclusions:

  • HIF-1 plays a critical role in the cellular and pathological responses to MI.
  • Targeting HIF-1 pathways presents a promising avenue for advancing MI treatment.
  • Further research into HIF-1 targeted therapies could lead to new clinical treatments for MI.

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