The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Area of Science:

• Pharmacology
• Drug Discovery
• Biochemistry

Background:

• The Concise Guide to Pharmacology is a biennial publication series.
• It summarizes key properties of drug targets and their interactions.
• It emphasizes selective pharmacology and provides links to an open-access knowledgebase.

Purpose of the Study:

• To provide a concise, citable, point-in-time record of pharmacological information.
• To present an overview of approximately 1800 drug targets and 6000 ligand interactions.
• To offer nomenclature guidance and information on pharmacological tools for major target classes.

Main Methods:

• Data compilation from biennial updates.
• Tabular format for presenting target and ligand properties.
• Inclusion of links to the Guide to Pharmacology knowledgebase (www.guidetopharmacology.org).

Main Results:

• Overview of ~1800 drug targets and ~3900 ligands with ~6000 interactions.
• Detailed information on ion channels, G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.
• Official IUPHAR classification and nomenclature for human drug targets.

Conclusions:

• The Concise Guide serves as a permanent, citable record of pharmacological data.
• It facilitates comparison of related targets with information current to mid-2023.
• It is a valuable resource for researchers and clinicians in pharmacology.