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Related Concept Videos

Non-gated Ion Channels01:24

Non-gated Ion Channels

6.8K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
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Ion Channels01:19

Ion Channels

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The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
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The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.3K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers01:22

Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers

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Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
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Related Experiment Video

Updated: Jul 7, 2025

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Stephen P H Alexander1, Alistair A Mathie2, John A Peters3

  • 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British Journal of Pharmacology
|December 20, 2023
PubMed
Summary
This summary is machine-generated.

The Concise Guide to Pharmacology 2023/24 offers a comprehensive overview of drug targets and their interactions. This biennial publication provides essential pharmacology data, including selective drug information and links to an extensive online knowledgebase.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biochemistry

Background:

  • The Concise Guide to Pharmacology is a biennial publication series.
  • It summarizes key properties of drug targets and their interactions.
  • It emphasizes selective pharmacology and provides links to an open-access knowledgebase.

Purpose of the Study:

  • To provide a concise, citable, point-in-time record of pharmacological information.
  • To present an overview of approximately 1800 drug targets and 6000 ligand interactions.
  • To offer nomenclature guidance and information on pharmacological tools for major target classes.

Main Methods:

  • Data compilation from biennial updates.
  • Tabular format for presenting target and ligand properties.
  • Inclusion of links to the Guide to Pharmacology knowledgebase (www.guidetopharmacology.org).

Main Results:

  • Overview of ~1800 drug targets and ~3900 ligands with ~6000 interactions.
  • Detailed information on ion channels, G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.
  • Official IUPHAR classification and nomenclature for human drug targets.

Conclusions:

  • The Concise Guide serves as a permanent, citable record of pharmacological data.
  • It facilitates comparison of related targets with information current to mid-2023.
  • It is a valuable resource for researchers and clinicians in pharmacology.