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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors
Stephen P H Alexander1, John A Cidlowski2, Eamonn Kelly3
1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
British Journal of Pharmacology
|December 20, 2023
Summary
The Concise Guide to Pharmacology 2023/24 offers a comprehensive overview of drug targets and their interactions. This biennial publication provides a citable record of pharmacological data, including nuclear hormone receptors and G protein-coupled receptors.
Area of Science:
- Pharmacology
- Drug Discovery
- Biochemistry
Background:
- The Concise Guide to Pharmacology is a biennial publication detailing drug targets and their interactions.
- The 2023/24 edition is the sixth in this series, building upon previous iterations.
- It includes information on approximately 1800 drug targets and 6000 ligand interactions.
Purpose of the Study:
- To provide a concise, tabular overview of key drug target properties and ligand interactions.
- To offer a permanent, citable record of pharmacological data as of mid-2023.
- To link users to an open-access knowledgebase for more detailed information.
Main Methods:
- Data compilation and summarization in a tabular format.
- Inclusion of selective pharmacology where available.
- Collaboration with the International Union of Basic and Clinical Pharmacology (IUPHAR) for nomenclature.
Main Results:
- Overview of ~1800 drug targets and ~6000 ligand interactions.
- Detailed information on nuclear hormone receptors, G protein-coupled receptors, catalytic receptors, enzymes, and transporters.
- Emphasis on selective pharmacology and official IUPHAR classification.
Conclusions:
- The Concise Guide serves as a valuable, up-to-date resource for pharmacological information.
- It provides a snapshot of the field, complementing the online knowledgebase.
- The publication facilitates comparison of related targets and supersedes previous editions.
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