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Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein-Drug Binding: Mechanism and Kinetics01:16

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Protein-drug binding refers to the interaction between drugs and proteins within the body. This binding process can occur intracellularly, involving drug interactions with enzymes or receptors within cells, or extracellularly, involving plasma proteins in the blood.
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Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

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Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
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Physiological Pharmacokinetic Models: Assumption with Protein Binding01:13

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Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets.

Stephen P H Alexander1, Eamonn Kelly2, Alistair A Mathie3

  • 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

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The Concise Guide to Pharmacology 2023/24 offers a comprehensive overview of drug targets and their interactions. This biennial publication provides essential pharmacology data for researchers and clinicians.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biochemistry

Background:

  • The Concise Guide to Pharmacology is a biennial publication series.
  • It provides overviews of drug targets and their interactions.
  • The latest edition is the sixth in the series, published in 2023/24.

Purpose of the Study:

  • To provide concise overviews of drug targets and ligand interactions.
  • To offer a permanent, citable record of pharmacological data.
  • To link to an open-access knowledgebase for detailed information.

Main Methods:

  • Data compilation in a tabular format.
  • Focus on selective pharmacology where available.
  • Inclusion of links to the www.guidetopharmacology.org knowledgebase.

Main Results:

  • Overview of approximately 1800 drug targets and 6000 interactions with 3900 ligands.
  • Categorization into six focus areas: GPCRs, ion channels, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.
  • Inclusion of 'Other protein targets' outside these categories.

Conclusions:

  • The Concise Guide serves as a valuable, up-to-date resource for pharmacological information.
  • It provides official IUPHAR classification and nomenclature for human drug targets.
  • The publication facilitates comparison of related targets and supersedes previous editions.