Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Enzymes01:22

Introduction to Enzymes

17.8K
The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that...
17.8K
Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

1.2K
Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
1.2K
Introduction to Enzyme Kinetics01:19

Introduction to Enzyme Kinetics

20.1K
Enzyme kinetics studies the rates of biochemical reactions. Scientists monitor the reaction rates for a particular enzymatic reaction at various substrate concentrations. Additional trials with inhibitors or other molecules that affect the reaction rate may also be performed.
The experimenter can then plot the initial reaction rate or velocity (Vo) of a given trial against the substrate concentration ([S]) to obtain a graph of the reaction properties. For many enzymatic reactions involving a...
20.1K
Catalytically Perfect Enzymes01:07

Catalytically Perfect Enzymes

4.0K
The theory of catalytically perfect enzymes was first proposed by W.J. Albery and J. R. Knowles in 1976. These enzymes catalyze biochemical reactions at high-speed. Their catalytic efficiency values range from 108-109 M-1s-1. These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. Examples include triose phosphate isomerase, fumarase, and superoxide dismutase.
 
Most enzymes...
4.0K
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

2.0K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.0K
Principles of Drug Action01:24

Principles of Drug Action

6.0K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.

Pharmacological reviews·2026
Same author

Structural basis for a filamentous morpheein model of human cystathionine beta-synthase.

Nature communications·2026
Same author

Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities.

Molecular neurobiology·2026
Same author

Just spit it out! How airway secretome analysis can inform us about epithelial metabolism.

American journal of respiratory cell and molecular biology·2026
Same author

Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the K<sub>v</sub>4 Channel Modulator, NS5806.

Pharmacology research & perspectives·2026
Same author

Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report.

Pharmacotherapy·2026

Related Experiment Video

Updated: Jul 7, 2025

Enzymatic Modification and Flow Cytometry Assessment of Yeast Surface Displayed Proteins
11:05

Enzymatic Modification and Flow Cytometry Assessment of Yeast Surface Displayed Proteins

Published on: May 30, 2025

195

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes.

Stephen P H Alexander1, Doriano Fabbro2, Eamonn Kelly3

  • 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British Journal of Pharmacology
|December 20, 2023
PubMed
Summary

The Concise Guide to Pharmacology 2023/24 offers a comprehensive overview of drug targets and their interactions. This biennial publication provides a citable record of pharmacological tools and IUPHAR classifications.

More Related Videos

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

590
Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

14.5K

Related Experiment Videos

Last Updated: Jul 7, 2025

Enzymatic Modification and Flow Cytometry Assessment of Yeast Surface Displayed Proteins
11:05

Enzymatic Modification and Flow Cytometry Assessment of Yeast Surface Displayed Proteins

Published on: May 30, 2025

195
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

590
Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

14.5K

Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biomedical Sciences

Background:

  • The Concise Guide to Pharmacology is a biennial publication.
  • It provides overviews of drug targets and their interactions.
  • The guide links to an open-access knowledgebase for detailed information.

Purpose of the Study:

  • To provide a concise, citable record of drug targets and ligands.
  • To offer an overview of selective pharmacology and available tools.
  • To present official IUPHAR classification and nomenclature for human drug targets.

Main Methods:

  • Compilation of data on approximately 1800 drug targets and 6000 interactions.
  • Focus on six key areas: GPCRs, ion channels, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.
  • Inclusion of nomenclature guidance, pharmacological tools, references, and further reading suggestions.

Main Results:

  • Presents key properties of drug targets and ligand interactions.
  • Highlights selective pharmacology where available.
  • Provides a permanent record superseding previous editions.

Conclusions:

  • The Concise Guide serves as a valuable, up-to-date resource for pharmacologists and researchers.
  • It facilitates comparison of related targets and provides access to curated information.
  • The publication ensures standardized nomenclature and classification for drug targets.