The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors

Area of Science:

• Pharmacology
• Drug Discovery
• Biomedical Research

Background:

• The Concise Guide to Pharmacology is a biennial publication series.
• It summarizes key properties of drug targets and their interactions.
• The guide links to an open-access knowledgebase for detailed information.

Purpose of the Study:

• To provide a concise, citable, point-in-time record of pharmacological data.
• To offer an overview of approximately 1800 drug targets and 6000 ligand interactions.
• To present official IUPHAR classification and nomenclature for human drug targets.

Main Methods:

• Data compilation in a tabular format.
• Inclusion of selective pharmacology where available.
• Cross-referencing with the online guide (https://www.guidetopharmacology.org/).

Main Results:

• Overview of ~1800 drug targets and ~6000 ligand interactions.
• Categorization of targets into six major groups: catalytic receptors, G protein-coupled receptors, ion channels, nuclear hormone receptors, enzymes, and transporters.
• Inclusion of nomenclature guidance and information on pharmacological tools.

Conclusions:

• The Concise Guide serves as a permanent, citable record of pharmacology data.
• It facilitates comparison of related targets.
• The publication provides essential resources for researchers in pharmacology and drug discovery.