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Related Experiment Videos

Double failure of the Type and Screen.

E A Mitten, K R Gregory, P J Schmidt

    American Journal of Clinical Pathology
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Type and Screen programs are efficient for blood crossmatching, but can miss rare antibodies. This study reports two instances where patients received incompatible blood due to such missed antibodies within a short period.

    Area of Science:

    • Transfusion Medicine
    • Immunology
    • Laboratory Science

    Background:

    • Type and Screen protocols are standard practice in transfusion services to optimize efficiency and safety.
    • These programs aim to reduce laboratory workload and costs associated with full crossmatching.

    Observation:

    • A critical limitation of Type and Screen is the potential to miss antibodies against low-prevalence donor antigens.
    • This can lead to the transfusion of antigen-positive blood to antibody-positive patients.

    Findings:

    • The authors document two separate incidents within a two-month timeframe at a single institution.
    • Both incidents involved patients with antibodies to low-incidence antigens missed by the Type and Screen protocol.
    • These patients subsequently received incompatible blood transfusions.

    Related Experiment Videos

    Implications:

    • Highlights the residual risk associated with Type and Screen protocols, particularly for rare antibodies.
    • Underscores the need for vigilance and potentially enhanced strategies to detect antibodies to low-frequency antigens.
    • Emphasizes the importance of robust patient safety measures in blood transfusion services.