Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

IR Spectrum Peak Splitting: Symmetric vs Asymmetric Vibrations01:08

IR Spectrum Peak Splitting: Symmetric vs Asymmetric Vibrations

2.0K
Identical bonds within a polyatomic group can stretch symmetrically (in-phase) or asymmetrically (out-of-phase). Similar to hydrogen bonding, these vibrations also influence the shape of the IR peak. Generally, asymmetric stretching frequencies are higher than symmetric stretching frequencies. For example, primary amines exhibit two distinct IR peaks between 3300–3500 cm−1 corresponding to the symmetric and asymmetric N-H stretching, while secondary amines exhibit a single...
2.0K
Simple Harmonic Motion01:21

Simple Harmonic Motion

11.5K
Simple harmonic motion is the name given to oscillatory motion for a system where the net force can be described by Hooke's law. If the net force can be described by Hooke's law and there is no damping (by friction or other non-conservative forces), then a simple harmonic oscillator will oscillate with equal displacement on either side of the equilibrium position. To derive an equation for period and frequency, the equation of motion is used. The period of a simple harmonic oscillator is given...
11.5K
Damped Oscillations01:07

Damped Oscillations

6.2K
In the real world, oscillations seldom follow true simple harmonic motion. A system that continues its motion indefinitely without losing its amplitude is termed undamped. However, friction of some sort usually dampens the motion, so it fades away or needs more force to continue. For example, a guitar string stops oscillating a few seconds after being plucked. Similarly, one must continually push a swing to keep a child swinging on a playground.
Although friction and other non-conservative...
6.2K
Forced Oscillations01:06

Forced Oscillations

6.3K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
6.3K
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

2.7K
An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
2.7K
Basic Discrete Time Signals01:16

Basic Discrete Time Signals

966
The unit step sequence is defined as 1 for zero and positive values of the integer n. This sequence can be graphically displayed using a set of eight sample points, showing a step function starting from n=0 and remaining constant thereafter.
The unit impulse or sample sequence is mathematically expressed as zero for all n values except at n=0, where it is one. The unit impulse sequence, denoted by δ(n), is the first difference of the unit step sequence, while the unit step sequence u(n) is...
966

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional reorganization of motor cortex connectivity during learning.

bioRxiv : the preprint server for biology·2026
Same author

Movie reconstruction from mouse visual cortex activity.

eLife·2026
Same author

Place cells in CA1 lack topographical organization of firing locations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability.

Science (New York, N.Y.)·2025
Same author

The emergence of NeuroAI: bridging neuroscience and artificial intelligence.

Nature reviews. Neuroscience·2025

Related Experiment Video

Updated: May 2, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
09:45

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

15.7K

Minute-scale oscillatory sequences in medial entorhinal cortex.

Soledad Gonzalo Cogno1, Horst A Obenhaus2, Ane Lautrup2

  • 1Kavli Institute for Systems Neuroscience and Centre for Algorithms in the Cortex, Fred Kavli Building, Norwegian University of Science and Technology, Trondheim, Norway. soledad.g.cogno@ntnu.no.

Nature
|December 20, 2023
PubMed
Summary

Researchers discovered ultraslow oscillations in the medial entorhinal cortex (MEC) of mice. These brain waves organize neuronal activity into sequences over minutes, potentially aiding spatial navigation and memory.

More Related Videos

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.8K
Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.9K

Related Experiment Videos

Last Updated: May 2, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
09:45

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

15.7K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.8K
Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.9K

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • The medial entorhinal cortex (MEC) is crucial for spatial navigation and episodic memory.
  • Neural activity in the MEC needs organization across long timescales (seconds to minutes) for these functions.
  • While spatial tuning of MEC cells is known, temporal organization of their activity over behaviorally relevant durations remains unclear.

Purpose of the Study:

  • To investigate the temporal organization of neuronal activity in the MEC over second-to-minute timescales.
  • To determine if MEC neuronal activity exhibits oscillatory patterns and sequential organization.
  • To explore the potential role of these temporal patterns in navigation and memory.

Main Methods:

  • Electrophysiological recordings of neuronal activity in the MEC of mice.
  • Analysis of neural activity during locomotion in a controlled environment (rotating wheel in darkness).
  • Comparison of oscillatory patterns in MEC with neighboring brain regions (parasubiculum, visual cortex).

Main Results:

  • MEC neuronal activity spontaneously organized into ultraslow oscillations (tens of seconds to minutes).
  • These oscillations contained periodic sequences involving a large portion of the MEC cell population.
  • Such oscillatory sequences were specific to the MEC and not observed in the parasubiculum or visual cortex.
  • Sequences persisted across immobility and were independent of location, direction, or reward.

Conclusions:

  • The MEC exhibits ultraslow oscillatory sequences, organizing neuronal activity across extended timescales.
  • These ultraslow oscillatory sequences may provide a framework for neural communication and sequence formation during navigation and memory.
  • This temporal organization in the MEC could be a fundamental mechanism for integrating experience over time.