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The intersection between ghrelin, metabolism and circadian rhythms
Soumya S Kulkarni1,2, Omprakash Singh2, Jeffrey M Zigman3,4,5
1Medical Scientist Training Program, UT Southwestern Medical Center, Dallas, TX, USA.
Nature Reviews. Endocrinology
|December 20, 2023
Summary
Ghrelin, a hormone, plays a key role in connecting sleep and metabolism by influencing and being influenced by your body's internal clock (circadian rhythms). This review explores ghrelin's impact on circadian outputs and how disruptions affect its secretion.
Area of Science:
- Circadian Biology
- Metabolism
- Endocrinology
Background:
- Growing public interest in sleep and diet highlights gaps in understanding circadian rhythms and metabolism.
- Ghrelin is a key hormone involved in appetite regulation and energy balance.
Purpose of the Study:
- To review the bidirectional relationship between ghrelin and circadian systems.
- To explore how ghrelin influences circadian rhythm outputs.
- To examine the effects of circadian rhythms on ghrelin and consequences of disruption.
Main Methods:
- Literature review synthesizing current research on ghrelin and circadian biology.
- Focus on ghrelin's impact on neuronal activity, growth hormone, locomotor activity, and eating behavior.
- Analysis of circadian effects on ghrelin expression and secretion.
Main Results:
- Ghrelin influences circadian outputs, including behavior and hormone levels.
- Circadian rhythms affect ghrelin expression and secretion patterns.
- Disrupted circadian patterns (e.g., shift work, jet lag) alter ghrelin secretion.
Conclusions:
- Ghrelin is a critical mediator in the interaction between circadian rhythms and metabolism.
- Understanding this bidirectional relationship is crucial for addressing metabolic health.
- Further research is needed to fully elucidate ghrelin's role in circadian regulation.
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