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Articles linked to this work by shared authors, journal, and citation graph.

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RAPIDIRON Trial follow-up study - the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study.

Richard J Derman1, Roopa B Bellad2, Mrutyunjaya B Bellad2

  • 1Thomas Jefferson University (TJU), Philadelphia, USA.

Trials
|December 21, 2023
PubMed
Summary
This summary is machine-generated.

The RAPIDIRON-KIDS study tracks infants born to mothers treated for anemia in pregnancy to assess neurodevelopment and iron status. This research aims to improve infant health outcomes by understanding the long-term effects of maternal anemia treatment.

Keywords:
AnemiaAnemia in pregnancyIron deficiency anemiaNeurodevelopment

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Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Nutritional Science

Background:

  • Anemia, primarily due to iron deficiency, is a significant global health issue, particularly in South Asia, affecting over half of pregnant women and 65% of children in India.
  • Maternal anemia during pregnancy is linked to adverse outcomes including preterm birth, low birth weight (LBW), and long-term neurodevelopmental problems in children.
  • The parent RAPIDIRON Trial investigated intravenous (IV) versus oral iron for anemic pregnant women, with this study extending the research to their offspring.

Purpose of the Study:

  • To evaluate the neurobehavioral, hematological, and overall health outcomes of infants born to mothers who participated in the RAPIDIRON Trial.
  • To assess infant iron status, cognitive development, and general health from birth up to 36 months of age.
  • To build upon the findings of the RAPIDIRON Trial by examining the long-term impact of maternal iron treatment on child development.

Main Methods:

  • A prospective observational cohort study following a subset of mothers and newborns from the RAPIDIRON Trial.
  • Regular study visits from birth to 36 months, including maternal and infant blood sample collection.
  • Infant neurobehavioral assessments using the Bayley Scales of Infant Development Version IV (BSID-IV) for cognitive domain evaluation.

Main Results:

  • Primary outcomes include infant iron status (hemoglobin and ferritin) at birth and 4 months, and cognitive developmental quotient (DQ) at 24 months.
  • Data collection is ongoing, with results anticipated to provide insights into infant health and development.
  • The study aims to determine the long-term effects of maternal iron supplementation on infant neurodevelopment and iron status.

Conclusions:

  • The RAPIDIRON-KIDS Study is a crucial follow-up to the RAPIDIRON Trial, extending the assessment period to three years of life for offspring.
  • It will provide comprehensive data on neurodevelopmental, hematological, and health outcomes in children exposed to different maternal anemia treatments in pregnancy.
  • Findings are expected to inform clinical practices and public health strategies for managing maternal anemia and its impact on child development.