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Critical hypertension in trauma patients following prehospital emergency anaesthesia: a multi-centre retrospective
Liam Sagi1, James Price2,3, Kate Lachowycz2
1Department of Research, Audit, Innovation, and Development, East Anglian Air Ambulance, Norwich, UK. Liam.sagi@eaaa.org.uk.
Insights
Prehospital emergency anaesthesia (PHEA) in trauma patients can lead to critical hypertension. Older age, lower GCS motor scores, higher pre-PHEA SBP, and multiple intubation attempts are key risk factors.
Area of Science:
- Emergency Medicine
- Trauma Surgery
- Anaesthesiology
Background:
- Critical hypertension in trauma patients correlates with higher mortality.
- Prehospital emergency anaesthesia (PHEA) is administered to 10% of severely injured patients.
- Optimizing physiological parameters is crucial for reducing secondary brain injury.
Purpose of the Study:
- To identify factors associated with critical hypertension following PHEA in trauma patients.
- To analyze a large regional dataset from three Helicopter Emergency Medical Service (HEMS) organizations.
Main Methods:
- Multi-center retrospective observational study (2015-2022).
- Included adult trauma patients undergoing PHEA.
- Critical hypertension defined as SBP >180mmHg or >10% increase post-PHEA.
- Logistic regression analysis to identify determinants.
Main Results:
- 11.9% of 1355 analyzed patients experienced post-PHEA critical hypertension.
- Independent predictors included increasing age, lower pre-PHEA GCS motor scores (4-5), pre-PHEA SBP >140mmHg, and multiple intubation attempts.
Conclusions:
- PHEA in trauma patients carries a risk of hemodynamic fluctuations, specifically critical hypertension.
- Age, GCS motor score, pre-PHEA SBP, and intubation attempts are significant independent predictors of post-PHEA critical hypertension.
Background:
Critical hypertension in major trauma patients is associated with increased mortality. Prehospital emergency anaesthesia (PHEA) is performed for 10% of the most seriously injured patients. Optimising oxygenation, ventilation, and cerebral perfusion, whilst avoiding extreme haemodynamic fluctuations are the cornerstones of reducing secondary brain injury. The aim of this study was to report the differential determinants of post-PHEA critical hypertension in a large regional dataset of trauma patients across three Helicopter Emergency Medical Service (HEMS) organisations.
Methods:
A multi-centre retrospective observational study of consecutive adult trauma patients undergoing PHEA across three HEMS in the United Kingdom; 2015-2022. Critical hypertension was defined as a new systolic blood pressure (SBP) > 180mmHg within 10 min of induction of anaesthesia, or > 10% increase if the baseline SBP was > 180mmHg prior to induction. Purposeful logistical regression was used to explore variables associated with post-PHEA critical hypertension in a multivariable model. Data are reported as number (percentage), and odds ratio (OR) with 95% confidence interval (95%CI).
Results:
30,744 patients were attended by HEMS during the study period; 2161 received PHEA and 1355 patients were included in the final analysis. 161 (11.9%) patients had one or more new episode(s) of critical hypertension ≤ 10 min post-PHEA. Increasing age (compared with 16-34 years): 35-54 years (OR 1.76, 95%CI 1.03-3.06); 55-74 years (OR 2.00, 95%CI 1.19-3.44); ≥75 years (OR 2.38, 95%CI 1.31-4.35), pre-PHEA Glasgow Coma Scale (GCS) motor score four (OR 2.17, 95%CI 1.19-4.01) and five (OR 2.82, 95%CI 1.60-7.09), patients with a pre-PHEA SBP > 140mmHg (OR 6.72, 95%CI 4.38-10.54), and more than one intubation attempt (OR 1.75, 95%CI 1.01-2.96) were associated with post-PHEA critical hypertension.
Conclusion:
Delivery of PHEA to seriously injured trauma patients risks haemodynamic fluctuation. In adult trauma patients undergoing PHEA, 11.9% of patients experienced post-PHEA critical hypertension. Increasing age, pre-PHEA GCS motor score four and five, patients with a pre-PHEA SBP > 140mmHg, and more than intubation attempt were independently associated with post-PHEA critical hypertension.
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