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Updated: Jul 7, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Published on: December 9, 2016

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Emerging role of competing endogenous RNA in lung cancer drug resistance

Shijie Wu1, Ting Luo1, Xiaoyong Lei1,2

  • 1School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang, People's Republic of China.

Journal of Chemotherapy (Florence, Italy)
|December 21, 2023
PubMed

Insights

Lung cancer drug resistance hinders treatment effectiveness. This review explores competing endogenous RNA (ceRNA) networks as a novel strategy to overcome chemoresistance in lung cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer has a low survival rate, with chemotherapy being a primary treatment.
  • Cellular resistance significantly limits the efficacy of chemotherapy in lung cancer.
  • The molecular basis of drug resistance in lung cancer requires further elucidation.

Purpose of the Study:

  • To review the role of competing endogenous RNA (ceRNA) networks in lung cancer.
  • To summarize therapeutic strategies targeting ceRNA networks to overcome drug resistance in lung cancer.

Main Methods:

  • This study is a narrative review of existing literature.
  • It focuses on the molecular mechanisms of ceRNA regulation.
  • The review synthesizes information on ceRNA involvement in cancer and drug resistance.

Main Results:

  • Accumulating evidence indicates ceRNAs participate in carcinogenesis and cancer development.
  • ceRNAs function by regulating each other through microRNA (miRNA) competition.
  • The specific relationship between ceRNAs and chemoresistance in lung cancer is an emerging area of research.

Conclusions:

  • ceRNA networks represent a promising avenue for understanding and potentially overcoming lung cancer chemoresistance.
  • Targeting ceRNA pathways could offer novel therapeutic strategies to improve patient outcomes in lung cancer.
Keywords:
Lung cancerceRNAscisplatindrug resistancenon-coding RNAtKI

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