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Updated: Jul 7, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Mouse models of diffuse large B cell lymphoma.

Areya Tabatabai¹, Aastha Arora¹, Svenja Höfmann¹

¹Department of Hematology and Stem Cell Transplantation, University Hospital Essen, West German Cancer Center, German Cancer Consortium Partner Site Essen, Center for Molecular Biotechnology, University of Duisburg-Essen, Essen, Germany.

Frontiers in Immunology

|December 21, 2023

Summary

This summary is machine-generated.

Developing accurate mouse models is crucial for understanding Diffuse Large B cell Lymphoma (DLBCL) heterogeneity and improving treatment strategies for patients with relapsed or refractory disease.

Keywords:

animal models diffuse large B cell lymphoma (DLBCL)genetically engineered (GE) animals lymphoma mouse models

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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

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Last Updated: Jul 7, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

Area of Science:

Oncology
Genetics
Immunology

Background:

Diffuse Large B cell Lymphoma (DLBCL) is a genetically diverse cancer.
Current treatments fail to cure 35% of patients, leading to relapsed or refractory disease.
Advanced treatments like CAR-T cells still face challenges in treating these patients.

Purpose of the Study:

To review the current state of mouse models for Diffuse Large B cell Lymphoma (DLBCL).
To highlight the importance of these models in capturing disease biology and heterogeneity.
To discuss genetically defined vulnerabilities and potential therapeutic targets.

Main Methods:

Discussion of existing literature on DLBCL mouse models.
Analysis of recent genomic characterization studies of DLBCL.
Focus on autochthonous, cell line-derived, and patient-derived mouse models.

Main Results:

Genomic studies provide a framework for creating better DLBCL mouse models.
Mouse models are essential for studying DLBCL biology and heterogeneity.
These models can inform the development of targeted therapies.

Conclusions:

Improved mouse models are needed to address the high unmet medical need in DLBCL.
Genetically defined molecular subgroups of DLBCL offer opportunities for targeted therapies.
Future research should focus on developing and validating sophisticated mouse models for DLBCL drug discovery.