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Relationship between β1-AA and AT1-AA and Cardiac Function in Patients with Hypertension Complicated with Left

Liang Wang1, Xue-Bai Lv2, Yu-Ting Yuan1

  • 1Department of Cardiology, Peking University International Hospital, Beijing 102206, China.

Cardiovascular Therapeutics
|December 21, 2023
PubMed

Insights

Autoantibodies against the β1 adrenergic receptor and angiotensin II type-1 receptor are independent risk factors for left ventricular diastolic dysfunction in hypertensive patients. These autoantibodies show predictive value, with combined detection offering the highest diagnostic accuracy.

Area of Science:

  • Cardiology
  • Immunology
  • Hypertension Research

Background:

  • Hypertension frequently complicates with left ventricular diastolic dysfunction (LVDD).
  • Autoantibodies, including β1 adrenergic receptor autoantibodies (β1-AA) and angiotensin II type-1 receptor autoantibodies (AT1-AA), are implicated in cardiovascular diseases.
  • The specific role of these autoantibodies in LVDD among hypertensive patients requires further elucidation.

Purpose of the Study:

  • To investigate the association between β1-AA and AT1-AA and cardiac function in hypertensive patients with LVDD.
  • To evaluate the diagnostic efficacy of β1-AA and AT1-AA as early markers for LVDD in essential hypertension.

Main Methods:

  • A cohort of 120 essential hypertension patients (untreated) were divided into LVDD (65 cases) and normal diastolic groups (55 cases).
  • Cardiac parameters, β1-AA, and AT1-AA levels were compared between groups.
  • Logistic regression analysis identified independent risk factors for LVDD; diagnostic efficacy was assessed using receiver operating characteristic (ROC) curves.

Main Results:

  • The LVDD group exhibited significantly higher levels of β1-AA and AT1-AA compared to the normal group (P < 0.05).
  • Multivariate analysis confirmed β1-AA (OR=1.96) and AT1-AA (OR=2.02) as independent risk factors for LVDD.
  • The combined detection of β1-AA and AT1-AA demonstrated a high diagnostic value for LVDD (AUC=0.942).

Conclusions:

  • Elevated levels of β1-AA and AT1-AA are associated with LVDD in essential hypertension.
  • Both β1-AA and AT1-AA serve as valuable early diagnostic markers for LVDD in hypertensive patients.
  • Combined assessment of these autoantibodies enhances diagnostic accuracy for LVDD.
Abstract

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