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Non-coding RNA and Drug resistance in cholangiocarcinoma

Zhaowei Wu1, Shiming Jiang1, Yong Chen1

  • 1Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Medical College Street, Yuzhong District, 404100, Chongqing, China.

Non-Coding RNA Research
|December 21, 2023
PubMed

Insights

Non-coding RNAs drive cholangiocarcinoma (bile duct cancer) drug resistance by altering key cancer pathways. Targeting these non-coding RNAs offers a promising strategy to overcome treatment resistance in this aggressive cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cholangiocarcinoma (bile duct cancer) is aggressive with poor outcomes and limited treatment options.
  • Chemotherapy resistance is a major challenge in managing advanced cholangiocarcinoma.
  • Mechanisms of chemotherapy resistance are complex and not fully understood.

Purpose of the Study:

  • To review the role of non-coding RNAs in cholangiocarcinoma drug resistance.
  • To summarize the molecular mechanisms by which non-coding RNAs confer resistance.
  • To highlight the therapeutic potential of targeting non-coding RNAs.

Main Methods:

  • Literature review of studies on non-coding RNAs and cholangiocarcinoma.
  • Analysis of molecular pathways involved in non-coding RNA-mediated drug resistance.
  • Synthesis of evidence on targeting non-coding RNAs for overcoming resistance.

Main Results:

  • Abnormal non-coding RNA expression is implicated in cholangiocarcinoma drug resistance.
  • Non-coding RNAs affect drug uptake, apoptosis, immune cell interaction, and cancer stemness.
  • Specific non-coding RNAs (microRNAs, long non-coding RNAs, circular RNAs) are key players.

Conclusions:

  • Non-coding RNAs are critical regulators of cholangiocarcinoma chemoresistance.
  • Targeting non-coding RNAs presents a novel therapeutic avenue.
  • Further research into non-coding RNA mechanisms can improve cholangiocarcinoma treatment strategies.
Keywords:
CholangiocarcinomaCirc RNADrug resistancelncRNAmiRNAncRNA

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