Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The dynamics of angular homeostasis: I. General principles.

E A Murphy, K R Berger

    American Journal of Medical Genetics
    |February 1, 1987
    PubMed
    Summary

    A new quantitative model describes cell growth, offering insights into developmental processes and genetic influences. This model explains how cell chains navigate and form complex structures, potentially impacting congenital defect research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Machine learning outperforms clinical experts in classification of hip fractures.

    Scientific reports·2022
    Same author

    The multiple effects of aspirin in prostate cancer patients.

    Cancer treatment and research communications·2020
    Same author

    Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota.

    Brain, behavior, and immunity·2019
    Same author

    Leptin resistance elicits depressive-like behaviors in rats.

    Brain, behavior, and immunity·2016
    Same author

    Role of MCP-1 on inflammatory processes and metabolic dysfunction following high-fat feedings in the FVB/N strain.

    International journal of obesity (2005)·2015
    Same author

    Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer.

    Cytokine·2014

    Area of Science:

    • Developmental Biology
    • Quantitative Modeling
    • Genetics

    Background:

    • Ontogeny, the development of an organism, involves complex cellular processes.
    • Understanding the genetic underpinnings of developmental pathways is crucial.
    • Existing models may not fully capture the quantitative aspects of cell growth and pattern formation.

    Purpose of the Study:

    • To propose a general, quantitative model for cell growth during ontogeny.
    • To analyze the genetic basis of developmental parameters like growth direction and error correction.
    • To explore how this model relates to biological phenomena, including congenital heart defects.

    Main Methods:

    • A computational model simulating a 'pursuer' cell chain growing towards a 'target' structure.
    • Incorporation of graduated directional correction and scale determinants (cell size, target distance).
    • Analysis of growth paths based on two key parameters: initial growth angle and correction force.

    Main Results:

    • The model demonstrates how cell growth paths are influenced by initial angle and correction force.
    • It explains the formation of various structures, including orbits around the target if missed.
    • Findings suggest potential for generating structures like cusps and circular membranes from cell growth.

    Conclusions:

    • The proposed quantitative model provides a framework for genetic analysis of developmental processes.
    • It offers insights into the formation of complex biological structures and potential links to congenital defects.
    • The model's parameters (initial angle, correction force) are identifiable as targets for genetic investigation.

    Related Experiment Videos