Related Experiment Video
Updated: Jul 7, 2025
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Is single point HbA1c a reliable predictor for death in severe COVID-19?
Hadiseh Hosamirudsari1, Yousef Alimohamadi2, Majid Akrami3
1Department of Infectious Diseases, Baharloo Hospital, Railway Square, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Single-point HbA1c levels did not predict COVID-19 severity or mortality in hospitalized patients. This finding suggests that routine HbA1c testing may not be a reliable indicator for managing COVID-19 outcomes in diabetic patients.
Area of Science:
- Medical Research
- Infectious Diseases
- Endocrinology
Background:
- Diabetes Mellitus (DM) is a known risk factor influencing COVID-19 severity.
- Assessing predictors of COVID-19 outcomes is crucial for patient management.
Purpose of the Study:
- To evaluate the association between single-point HbA1c measurements and the severity and mortality of hospitalized COVID-19 patients.
- To determine if HbA1c can serve as a predictive marker for COVID-19 outcomes.
Main Methods:
- A cross-sectional study involving 165 hospitalized COVID-19 patients (moderate to severe) diagnosed via PCR and CT imaging.
- Data collected included demographics, clinical presentation, laboratory results (including single-point HbA1c and Fasting Blood Sugar - FBS), and treatments.
- Statistical analysis was performed to assess the relationship between HbA1c, FBS, and COVID-19 severity and mortality.
Main Results:
- The study included 165 patients, with 76.4% classified as severe COVID-19 cases.
- Severe cases experienced longer hospital stays and higher inflammatory mediator levels (p < 0.05).
- No statistically significant association was found between single-point HbA1c or FBS and COVID-19 severity or mortality (p > 0.05).
Conclusions:
- Single-point HbA1c measurements are not a reliable predictor for COVID-19 severity or mortality in hospitalized patients.
- Further research may be needed to explore other glycemic control markers or factors in relation to COVID-19 outcomes.
Introduction:
The severity of COVID-19 infection is affected by several risk factors such as Diabetes Mellitus (DM). The current study aimed to determine the effect of single-point HbA1c on the severity and mortality of hospitalized COVID-19 patients.
Methods:
This cross-sectional study was conducted among hospitalized moderate and severe COVID-19 patients in Baharloo Hospital in Iran between December 23rd and February 23rd, 2021. The patients have been diagnosed by Polymerase Chain Reaction (PCR) and Chest Computed Tomography (CT) imaging as COVID-19. Demographic data, clinical presentation, laboratory results, and treatments along with the HbA1c data were included.
Results:
165 COVID-19 cases were included in this study; 126 (76.4%) of which were severe cases. 89 (53.9%) patients were male, with a mean age of 59.89 ± 16.59 years. Severe COVID-19 patients were more prone to a longer hospital stay, and a higher level of inflammatory mediators, compared to the moderate COVID-19 patients (p < 0.05). No significant association was found between single point HbA1c, FBS, and severity and mortality of COVID-19 cases (p > 0.05).
Conclusions:
Single point HbA1c was not a reliable mediator for the prediction of severity or death in hospitalized COVID-19 patients.
More Related Videos
05:15Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
07:24A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
