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Myxoinflammatory fibroblastic sarcoma: ultrastructural study of 7 cases
Guillermo Ernesto Corredor-Alonso1, Claudia Haydee Sarai Caro-Sánchez2, Hugo Ricardo Domínguez-Malagón2
1AstraZeneca Computational Pathology GmbH, Deutschland.
Ultrastructural Pathology
|December 21, 2023
Summary
This study details the ultrastructural features of Myxoinflammatory fibroblastic sarcomas (MIFS), revealing characteristic cellular changes like "soccer ball" cells and macrophagic differentiation. These findings enhance understanding of MIFS morphology and its potential continuum.
Area of Science:
- Oncology
- Pathology
- Electron Microscopy
Background:
- Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue tumor.
- Existing literature extensively covers clinicopathological and immunohistochemical aspects of MIFS.
- Ultrastructural findings of MIFS remain incompletely documented.
Purpose of the Study:
- To elucidate the ultrastructural characteristics of Myxoinflammatory fibroblastic sarcomas.
- To correlate ultrastructural findings with immunohistochemical and histological features.
- To contribute to a comprehensive understanding of MIFS morphology.
Main Methods:
- Seven cases of MIFS were analyzed using transmission electron microscopy.
- Tissue samples were processed from paraffin blocks after immunohistochemistry.
- Automatized staining devices were employed for sample preparation.
Main Results:
- Histology revealed typical MIFS features, including Reed-Sternberg-like cells, pseudolipoblasts, and emperipolesis.
- Two cases showed high-grade components: one with osteoclastic giant cells, another with Hodgkin-like inflammation.
- Ultrastructural analysis identified dilated rough endoplasmic reticulum forming "soccer ball" cells, abundant lysosomes, phagolysosomes, and intermediate filaments.
Conclusions:
- Ultrastructural findings support MIFS as a morphologic continuum.
- The study highlights a modified fibroblastic phenotype with variable macrophagic differentiation.
- These ultrastructural details provide critical insights into MIFS pathogenesis and classification.
