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Updated: Aug 3, 2026
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Multi-Enzyme Activity of MIL-101 (Fe)-Derived Cascade Nano-Enzymes for Antitumor and Antimicrobial Therapy
Mengmeng Sun1, Liling Wang1, Yong Zhuo2
1College of Science, Sichuan Agricultural University, Xin Kang Road, Yucheng District, Ya'an, 625014, P. R. China.
Abstract:
The clinical application of oncology therapy is hampered by high glutathione concentrations, hypoxia, and inefficient activation of cell death mechanisms in cancer cells. In this study, Fe and Mo bimetallic sulfide nanomaterial (FeS2@MoS2) based on metal-organic framework structure is rationally prepared with peroxidase (POD)-, catalase (CAT)-, superoxide dismutase (SOD)-like activities and glutathione depletion ability, which can confer versatility for treating tumors and mending wounds. In the lesion area, FeS2@MoS2 with SOD-like activity can facilitate the transformation of superoxide anions (O2 -) to hydrogen peroxide (H2O2), and then the resulting H2O2 serves as a substrate for the Fenton reaction with FMS to produce highly toxic hydroxyl radicals (∙OH). Simultaneously, FeS2@MoS2 has an ability to deplete glutathione (GSH) and catalyze the decomposition of nicotinamide adenine dinucleotide phosphate (NADPH) to curb the regeneration of GSH from the source. Thus it can realize effective tumor elimination through synergistic apoptosis-ferroptosis strategy. Based on the alteration of the H2O2 system, free radical production, glutathione depletion and the alleviation of hypoxia in the tumor microenvironment, FeS2@MoS2 NPS can not only significantly inhibit tumors in vivo and in vitro, but also inhibit multidrug-resistant bacteria and hasten wound healing. It may open the door to the development of cascade nanoplatforms for effective tumor treatment and overcoming wound infection.
Insights
This study introduces a novel iron and molybdenum bimetallic sulfide nanomaterial (FeS2@MoS2) that effectively combats tumors and infections. The nanomaterial depletes glutathione and generates toxic hydroxyl radicals, inhibiting cancer growth and aiding wound healing.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Cancer therapy faces challenges from high glutathione levels, hypoxia, and poor cell death induction.
- Developing versatile nanomaterials is crucial for effective tumor treatment and infection management.
Purpose of the Study:
- To synthesize and characterize a Fe and Mo bimetallic sulfide nanomaterial (FeS2@MoS2) for synergistic tumor elimination and wound healing.
- To investigate the nanomaterial's peroxidase-, catalase-, and superoxide dismutase-like activities, and its glutathione depletion capability.
Main Methods:
- Preparation of FeS2@MoS2 nanomaterial based on a metal-organic framework structure.
- Evaluation of nanomaterial's enzymatic activities and glutathione depletion ability.
- Assessment of tumor inhibition in vitro and in vivo, antibacterial activity, and wound healing efficacy.
Main Results:
- FeS2@MoS2 exhibits POD, CAT, and SOD-like activities, facilitating hydroxyl radical production via Fenton reaction.
- The nanomaterial effectively depletes glutathione (GSH) and nicotinamide adenine dinucleotide phosphate (NADPH), inhibiting GSH regeneration.
- FeS2@MoS2 demonstrated significant tumor inhibition, antibacterial effects against multidrug-resistant bacteria, and accelerated wound healing.
Conclusions:
- FeS2@MoS2 nanomaterials offer a promising cascade nanoplatform for synergistic apoptosis-ferroptosis tumor therapy.
- The developed nanomaterial effectively addresses tumor microenvironment challenges like hypoxia and glutathione accumulation.
- FeS2@MoS2 shows potential for treating tumors, overcoming multidrug resistance, and promoting wound healing.
