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Updated: Jul 7, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Et2 Zn-Mediated Gem-Dicarboxylation of Cyclopropanols with CO2
Hongjian Liu1, Lei Shi2, Xiaobin Tan1
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Abstract:
An unprecedented Et2 Zn-mediated gem-dicarboxylation of C─C/C─H single bond of cyclopropanols with CO2 is disclosed, which provides a straightforward and efficient methodology for the synthesis of a variety of structurally diverse and useful malonic acids in moderate to excellent yields. The protocol features mild reaction conditions, excellent functional group compatibility, broad substrate scope, and facile derivatization of the products. DFT calculations confirm that the transition-metal-free transformation proceeds through a novel ring-opening/α-functionalization/ring-closing/ring-opening/β-functionalization (ROFCOF) process, and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) plays dual important roles in the transformation.
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