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Sinoaortic denervation in the nonhuman primate.

V S Bishop, R E Shade, J R Haywood

    The American Journal of Physiology
    |February 1, 1987
    PubMed
    Summary
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    Baroreceptor denervation in baboons causes acute hypertension and increased blood pressure variability. While pressure levels decrease over time, they remain elevated four weeks post-surgery, impacting cardiovascular regulation.

    Area of Science:

    • Cardiovascular Physiology
    • Neuroscience
    • Primate Research

    Background:

    • Baroreceptor reflexes are crucial for regulating blood pressure, especially during postural changes.
    • The sustained effects of baroreceptor denervation on blood pressure in primates remain controversial.
    • Understanding these effects is vital for comprehending cardiovascular control mechanisms.

    Purpose of the Study:

    • To investigate the acute and sustained effects of baroreceptor deafferentation on arterial pressure in baboons.
    • To determine if baroreceptor denervation leads to sustained hypertension in primates.
    • To assess changes in arterial pressure lability following baroreceptor denervation.

    Main Methods:

    • Six adult male baboons (Papio anubis) underwent aortic denervation followed by sinoaortic deafferentation.

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  • Mean arterial pressure (MAP) and its lability were monitored over a 4-week period using a tether system.
  • Data analysis focused on comparing pre- and post-denervation pressure levels and variability.

    • Main Results:

    • Aortic denervation acutely increased mean arterial pressure (MAP) from 86 to 105 mmHg.
    • Following complete baroreceptor denervation, MAP rose to 129 mmHg at 1 week and settled at 97 mmHg by 4 weeks.
    • Arterial pressure lability significantly increased after complete baroreceptor denervation, persisting at 4 weeks.

    Conclusions:

    • Baroreceptor deafferentation in primates causes an initial rise in arterial pressure and heart rate.
    • While arterial pressure and its lability decrease by 4 weeks, they remain significantly elevated compared to baseline.
    • These findings highlight the critical role of baroreceptors in maintaining stable blood pressure in primates.