Acute myeloid leukemia: Current understanding and management.
Michelle Becker1, Kyle A Farina, John Mascarenhas
1Michelle Becker practices in the adult leukemia program at the Icahn School of Medicine at Mount Sinai in New York, N.Y. Kyle A. Farina is a clinical pharmacy manager, working on the leukemia service at Mount Sinai Hospital in New York, N.Y. John Mascarenhas is director of the adult leukemia program, leader of the Myeloproliferative Disorders Clinical Research Program in the Division of Hematology/Oncology at the Tisch Cancer Institute at Mount Sinai Hospital, and a professor of medicine at the Icahn School of Medicine at Mount Sinai. Dr. Farina discloses that he is a consultant and speaker for Bristol Myers Squibb. Dr. Mascarenhas discloses that he is a consultant for Celgene Corp., Bristol Myers Squibb Co., Incyte Inc., F. Hoffmann-La Roche AG, PharmaEssentia Corp., Geron Corp., CTI Biopharma Corp., MorphoSys AG, Abbvie Inc., Kartos Therapeutics, Novartis AG, Sierra Oncology Inc., GSK plc, Karyopharm Therapeutics Inc., Galecto Inc., Imago BioSciences Inc., and Pfizer Inc., and receives research funding from Bristol Myers Squibb, Abbvie, CTI Biopharma, Incyte, Merck & Co., Novartis, Roche, Kartos, PharmaEssentia, and Geron. The authors have disclosed no other potential conflicts of interest, financial or otherwise.
Acute myeloid leukemia (AML) is the most common adult acute leukemia, demanding prompt treatment for survival. Accurate classification and comprehensive supportive care are crucial for managing this aggressive cancer.
Area of Science:
- Hematology
- Oncology
Background:
- Acute myeloid leukemia (AML) is the predominant acute leukemia in adults, characterized by poor prognosis.
- Timely intervention is essential for improving patient outcomes in AML.
Purpose of the Study:
- To provide a comprehensive overview of acute myeloid leukemia (AML).
- To discuss current treatment strategies and supportive care for AML patients.
Main Methods:
- Review of current literature and clinical guidelines for AML diagnosis and management.
- Discussion of World Health Organization (WHO) classification criteria for AML prognosis.
Main Results:
- AML classification via WHO criteria guides risk-adapted therapy.
- Supportive care, including transfusions and antimicrobial treatments, is vital during chemotherapy.
Conclusions:
- Early recognition of AML signs is critical for all clinicians.
- Patients require specialized care from hematologist/oncologists for optimal management.
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