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Causal relationship between frailty and chronic obstructive pulmonary disease or asthma: A two sample bidirectional
Jingge Qu1, Ying Liang1, Yafei Rao1
1Department of Respiratory and Critical Care Medicine, Research Center for Chronic Airway Diseases, Peking University Third Hospital, Peking University Health Science Center, 49 North Garden Road, Haidian District, Beijing, PR China.
This study found that frailty increases the risk of chronic obstructive pulmonary disease (COPD) and asthma, and conversely, these lung diseases increase frailty. Understanding this link is crucial for disease prevention and treatment.
Area of Science:
- Genetics
- Epidemiology
- Gerontology
Background:
- Observational studies suggest a link between frailty and obstructive lung diseases, but causality is unproven.
- Investigating the bidirectional causal relationship between frailty and obstructive lung diseases is essential for clinical understanding.
Approach:
- A bidirectional Mendelian randomization (MR) study was performed using genome-wide association study data.
- Genetic instruments for frailty index (FI), COPD, and asthma were derived from large-scale European ancestry cohorts.
- Standard MR methods including IVW, weighted median, MR-Egger, and MR-PRESSO were employed for robust analysis.
Key Points:
- Genetically predicted higher FI was associated with an increased risk of COPD (OR 1.75) and asthma (OR 2.10).
- Genetic liability to COPD (beta 0.06) and asthma (beta 0.08) was significantly associated with a higher FI.
- Results demonstrate a reciprocal causal relationship between frailty and obstructive lung diseases.
Conclusions:
- The study confirms a bidirectional causal link between frailty and obstructive lung diseases.
- Understanding this interplay is vital for developing effective prevention and treatment strategies for COPD and asthma.
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