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Reference Ranges for Left Modified Myocardial Performance Index: Systematic Review and Meta-Analysis.
Katherine H Bligard1, Michelle Doering2, Shay Porat3
1Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
The modified myocardial performance index (mod-MPI) increases with fetal development, but clear reference ranges for normal fetuses are still needed. Further research is required to standardize this tool for assessing fetal cardiac function.
Area of Science:
- Cardiology
- Fetal Medicine
- Medical Imaging
Background:
- The modified myocardial performance index (mod-MPI) is a noninvasive Doppler-derived metric for fetal cardiac function assessment.
- Current reference ranges for mod-MPI in normal fetuses are not well-defined, limiting its clinical utility in cases of suspected fetal cardiac compromise.
Conclusions:
- While mod-MPI generally increases throughout gestation, definitive reference ranges for fetal assessment remain elusive.
- There is a critical need for optimized and automated methods for calculating time intervals to improve the reproducibility of mod-MPI.
- Standardization is essential for the reliable application of mod-MPI as a tool for evaluating fetal cardiac function.
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