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Interplay of inflammatory biomarkers in heart disease patients with depressive symptoms: An update

Treesa P Varghese1, Sharad Chand2, Nila Mary Varghese3

  • 1Associate Professor, Department of Pharmacy Practice, Yenepoya Pharmacy College & Research Centre (Yenepoya deemed to be University), Naringana, Mangalore, Karnataka, India.

Current Problems in Cardiology
|December 21, 2023
PubMed

Insights

Inflammation links heart disease and depression through shared mechanisms like endothelial dysfunction. Inflammatory biomarkers may predict depressive symptoms in cardiac patients.

Area of Science:

  • Cardiovascular Medicine
  • Psychiatry
  • Immunology

Background:

  • Heart disease and depression share pathophysiological links including endothelial dysfunction, Hypothalamic Pituitary Adrenal (HPA) axis dysregulation, and abnormal platelet activity.
  • Low-grade inflammation influences both endothelial dysfunction and HPA axis dysregulation, suggesting a central role in the co-occurrence of these conditions.
  • Inflammation is implicated in atherosclerotic plaque formation, involving intercellular adhesion molecules (ICAMs) and inflammatory markers.

Purpose of the Study:

  • To review the role of inflammatory biomarkers in heart disease and depression.
  • To assess the potential of these biomarkers in predicting depressive symptoms in patients with heart disease.

Main Methods:

  • Literature review focusing on inflammatory mediators.
  • Analysis of the connection between inflammation, endothelial function, HPA axis, and platelet activity.
  • Evaluation of specific inflammatory markers such as soluble ICAM-1, interleukin-6, Tumour Necrosis Factor, and C-reactive protein.

Main Results:

  • Inflammation is a key factor in the pathophysiology linking heart disease and depression.
  • Soluble ICAM-1, interleukin-6, TNF, and CRP are implicated as significant inflammatory markers.
  • These markers are associated with both cardiovascular disease development and depressive symptoms.

Conclusions:

  • Inflammatory biomarkers play a crucial role in the interplay between heart disease and depression.
  • Investigating these biomarkers may offer predictive value for identifying depressive symptoms in cardiac patients.
  • Targeting inflammation could be a therapeutic strategy for managing comorbid heart disease and depression.

Keywords:
C-reactive proteinCardiac diseasesDepressionHypothalamic pituitary adrenal axisInterleukin-6Soluble intercellular adhesion moleculesTumor necrosis factor

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