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Biolistic Transformation of a Fluorescent Tagged Gene into the Opportunistic Fungal Pathogen Cryptococcus neoformans

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Published on: March 19, 2015

Multi-locus sequence typing and phylogenetics of Cryptococcus neoformans AD hybrids.

M Cogliati¹, P E Chidebelu², M Hitchcock³

¹Lab. Medical Mycology, Dept. Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.

Fungal Genetics and Biology : FG & B

|December 21, 2023

Summary

Cryptococcus neoformans AD hybrid strains have diverse origins and evolve dynamically. Genotyping these hybrids reveals new genetic diversity, aiding in understanding their evolution and spread globally.

Keywords:

AD hybrids Cryptococcus neoformans Loss of heterozygosity MLST Multiple origin Phylogenetics

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Area of Science:

Medical Mycology
Population Genetics
Evolutionary Biology

Background:

Hybrid AD strains of Cryptococcus neoformans are globally distributed but poorly understood.
Their origins, diversity, and evolutionary dynamics require further investigation.

Purpose of the Study:

To analyze the origin, diversity, and evolution of Cryptococcus neoformans AD hybrid strains.
To compare AD hybrids with global haploid serotypes A and D strains.

Main Methods:

Genotyping of 102 AD hybrid strains from 21 countries using mating type and seven-locus sequencing.
Phylogenetic and population genetic analyses of allelic sequences.
Comparison of AD hybrids with global haploid serotype A and D strains.

Main Results:

Most AD hybrids showed loss of heterozygosity at analyzed loci.
Phylogenetic analyses indicated multiple hybrid origins across continents, dating back one million years.
Evidence for clonal reproduction, long-distance dispersal, and novel genetic diversity in AD hybrids and haploid populations was found.

Conclusions:

AD hybrids can be effectively genotyped using established multi-locus sequencing typing methods.
Novel genetic diversity exists in AD hybrids and haploid populations.
AD hybrids exhibit multiple origins and dynamic evolution in nature.