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Non-coding RNAs in Recurrent implantation failure
Mazyar Zahir1, Bahareh Tavakoli2, Majid Zaki-Dizaji3
1Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Non-coding RNAs play a crucial role in recurrent implantation failure (RIF), a challenge in in-vitro fertilization (IVF). Understanding these molecules offers potential for improved IVF success rates.
Area of Science:
- Reproductive Medicine
- Molecular Biology
- Genetics
Background:
- Recurrent implantation failure (RIF) is a complex challenge in assisted reproduction, impacting IVF success.
- The intricate molecular mechanisms underlying RIF are still being elucidated.
- Non-coding RNAs (ncRNAs) have emerged as critical regulators in reproductive processes.
Purpose of the Study:
- To comprehensively review the role of non-coding RNAs in the pathogenesis of RIF.
- To explore the potential of ncRNAs as diagnostic biomarkers for RIF.
- To highlight ncRNAs as therapeutic targets for improving IVF outcomes.
Main Methods:
- Literature review of studies investigating ncRNAs in RIF.
- Analysis of the involvement of microRNAs, circular RNAs, and long non-coding RNAs in implantation.
- Synthesis of current understanding of ncRNA dysregulation in RIF.
Main Results:
- Non-coding RNAs, including microRNAs, circular RNAs, and long non-coding RNAs, are integral to endometrial receptivity and maternal-embryonic interactions.
- Aberrant expression of ncRNAs disrupts the delicate balance required for successful embryo implantation.
- Dysregulated ncRNAs are implicated in the etiopathogenesis of RIF.
Conclusions:
- Non-coding RNAs are significantly involved in the development of RIF.
- ncRNAs hold promise as potential biomarkers for diagnosing RIF.
- Targeting ncRNAs may offer novel therapeutic strategies to enhance implantation success in IVF.
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