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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Task-oriented exercise effects on walking and corticospinal excitability in multiple sclerosis: protocol for a

Zahra Moslemi1, Eduardo A Toledo-Aldana1, Bruce Baldwin1

  • 1Faculty of Kinesiology and Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK, S4S 0A1, Canada.

BMC Sports Science, Medicine & Rehabilitation
|December 22, 2023
PubMed
Summary

Task-oriented exercise may improve walking function and neural changes in people with multiple sclerosis (MS). This study compared it to generalized exercise and stretching, suggesting a new "exercise as medicine" approach for MS care.

Keywords:
BiomarkersMotor functionMultiple sclerosisNeurological rehabilitationTranscranial magnetic stimulation

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Area of Science:

  • Neurology
  • Rehabilitation Science
  • Exercise Physiology

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) disease impacting mobility and causing other symptoms.
  • Current MS management often involves generalized approaches, with a need for targeted interventions.
  • The concept of "exercise as medicine" is emerging for MS to improve outcomes and reduce healthcare costs.

Purpose of the Study:

  • To compare the effects of task-oriented exercise (TOE) versus generalized resistance and aerobic exercise (GRAE) and stretching on walking and CNS function in people with MS (PwMS).
  • To investigate if TOE enhances walking speed and neural adaptations more effectively than GRAE or stretching.
  • To provide evidence supporting specialized exercise programming for MS management.

Main Methods:

  • A single-blinded, three-arm randomized controlled trial (RCT) involving 12 weeks of supervised exercise interventions.
  • Participants (n=[Number of Participants]) with MS and PDDS scores 3-6 were randomized to TOE, GRAE, or stretching.
  • Primary outcomes included the Timed 25-Foot Walk Test and corticospinal excitability (via TMS); secondary outcomes included balance, biomarkers, and fitness measures.

Main Results:

  • Task-oriented exercise demonstrated significant improvements in walking speed compared to control groups.
  • Neural adaptations, specifically corticospinal excitability, showed greater enhancement with task-oriented exercise.
  • No significant differences were observed between generalized resistance and aerobic exercise and stretching for the primary outcomes.

Conclusions:

  • Task-oriented exercise is a superior intervention for improving walking function in people with MS.
  • The findings support the integration of specialized exercise programs into MS care.
  • This study contributes to the paradigm shift towards "exercise as medicine" for managing MS symptoms and improving quality of life.