Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
Drug Dependence01:17

Drug Dependence

1.0K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.0K
Types of Damping01:20

Types of Damping

6.4K
If the amount of damping in a system is gradually increased, the period and frequency start to become affected because damping opposes, and hence slows, the back and forth motion (the net force is smaller in both directions). If there is a very large amount of damping, the system does not even oscillate; instead, it slowly moves toward equilibrium. In brief, an overdamped system moves slowly towards equilibrium, whereas an underdamped system moves quickly to equilibrium but will oscillate about...
6.4K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Time Course of Drug Effect01:14

Time Course of Drug Effect

2.1K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.1K
Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

3.1K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How Safe Are COVID-19 Vaccines in Individuals with Immune-Mediated Inflammatory Diseases? The SUCCEED Study.

Vaccines·2024
See all related articles

Related Experiment Video

Updated: Jul 7, 2025

Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

15.4K

A Journey Through Tapering.

Linda Wilhelm1

  • 1Canadian Arthritis Patient Alliance, Bloomfield, Canada.

Journal of Patient Experience
|December 22, 2023
PubMed
Summary

Patients with severe rheumatoid arthritis (RA) face challenges managing pain, including risks associated with long-term opioid use. Current policies restrict opioid access and tapering support, highlighting a critical gap in Canadian healthcare resources.

Area of Science:

  • Rheumatology
  • Pain Management
  • Public Health Policy

Background:

  • Rheumatoid arthritis (RA) presents significant long-term management challenges, impacting patient quality of life.
  • Opioid therapy has been used to manage severe RA pain, but carries substantial risks and long-term dependence concerns.
  • The current opioid crisis has led to policy changes restricting access and encouraging tapering.

Purpose of the Study:

  • To examine the patient experience with long-term opioid use for severe rheumatoid arthritis.
  • To highlight the challenges faced by patients during opioid tapering.
  • To identify the lack of adequate support systems for patients undergoing opioid tapering in Canada.

Main Methods:

  • Qualitative patient narrative.
Keywords:
health planning and policyopioidstapering

More Related Videos

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
04:37

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

878
Author Spotlight: Development of a Standardized Acupuncture Tool Inspired by Advanced Techniques for Improved Safety and Precision
07:29

Author Spotlight: Development of a Standardized Acupuncture Tool Inspired by Advanced Techniques for Improved Safety and Precision

Published on: January 10, 2025

328

Related Experiment Videos

Last Updated: Jul 7, 2025

Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

15.4K
Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
04:37

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

878
Author Spotlight: Development of a Standardized Acupuncture Tool Inspired by Advanced Techniques for Improved Safety and Precision
07:29

Author Spotlight: Development of a Standardized Acupuncture Tool Inspired by Advanced Techniques for Improved Safety and Precision

Published on: January 10, 2025

328
  • Retrospective review of treatment challenges.
  • Analysis of policy impact on patient care.

    • Main Results:

    • Patients with severe RA experienced difficulties in diagnosis and long-term medication efficacy.
    • Opioid prescription provided temporary relief but lacked discussion on cessation challenges.
    • Current policies create pressure to taper opioids without sufficient patient support resources in Canada.

    Conclusions:

    • Long-term opioid therapy for RA, while providing quality of life improvements, poses significant risks and cessation challenges.
    • The shift in opioid policy necessitates increased funding and resources for patient support during tapering.
    • There is a critical need for comprehensive support services to aid patients in navigating opioid tapering within the Canadian healthcare system.