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Effectiveness of Rituximab and Its Biosimilar in Treating Adult Steroid-Dependent Minimal Change Disease and Relapse

Hui Yi Shan1

  • 1Nephrology and Hypertension, Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, USA.

Cureus
|December 22, 2023
PubMed

Insights

Rituximab (RTX) and its biosimilar, ruxience, effectively treat adult minimal change disease (MCD) relapses and steroid dependence. This study highlights their successful use in managing this challenging nephrotic syndrome in adults.

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Minimal change disease (MCD) is a primary cause of nephrotic syndrome in adults.
  • Adult MCD cases frequently involve challenging relapses and steroid dependence.
  • Limited adult-specific treatment data exists, with most experience from pediatric cases.
Keywords:
frequent relapsesminimal change diseaserituximabrituximab biosimilarruxiencesteroid-dependent minimal change disease

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