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Updated: Jul 7, 2025
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges
Ya-Nan Wei1, Chun-Yan Yan1, Meng-Lu Zhao1
1Department of Clinical Oncology, Sheng jing Hospital of China Medical University, Shenyang 110022, People's Republic of China.
Abstract:
Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the tumor microenvironment via EVs. In this article, we describe the roles of EVs in the tumor immune microenvironment, metabolic microenvironment, and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens, and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.
Insights
Extracellular vesicles (EVs) are crucial in intercellular communication and cancer development. These EVs show promise for targeted drug delivery and treating diseases like triple-negative breast cancer (TNBC).
Area of Science:
- Biomedical Engineering
- Molecular Biology
- Oncology
Background:
- Extracellular vesicles (EVs) mediate intercellular crosstalk, carrying biomolecules like DNA, RNA, and proteins.
- Triple-negative breast cancer (TNBC) presents significant challenges due to its metastatic nature and lack of targeted therapies.
- EVs play a critical role in the development and progression of TNBC by influencing the tumor microenvironment.
Purpose of the Study:
- To elucidate the multifaceted roles of EVs in the tumor microenvironment of TNBC.
- To explore the application of EVs in targeted drug delivery systems.
- To review the potential of EVs in cancer immunotherapy and vaccine development.
Main Methods:
- Review of existing literature on EVs in cancer biology and therapeutics.
- Analysis of EV composition and function in intercellular communication.
- Evaluation of EV-based strategies for drug delivery and immunotherapy.
Main Results:
- EVs are implicated in shaping the immune, metabolic, and vascular aspects of the tumor microenvironment.
- EVs facilitate the targeted delivery of chemotherapeutic agents, immune antigens, and vaccine adjuvants.
- The study highlights the significant potential of EVs in therapeutic applications for various diseases.
Conclusions:
- EVs are pivotal in TNBC pathogenesis and represent a promising platform for next-generation targeted therapies.
- EV-based therapeutic strategies offer a novel approach for treating diseases with limited effective treatment options.
- Further research into EV-mediated mechanisms can unlock new avenues for cancer treatment and drug delivery.
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