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Related Experiment Videos

Endotracheal diazepam: absorption and pulmonary pathologic effects.

M Rusli, W H Spivey, H Bonner

    Annals of Emergency Medicine
    |March 1, 1987
    PubMed
    Summary
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    Endotracheal diazepam (intratracheal) is absorbed effectively but causes lung inflammation (pneumonitis) in cats. This suggests caution is needed for this route of administration due to potential adverse pulmonary effects.

    Area of Science:

    • Veterinary Medicine
    • Pharmacology
    • Pulmonary Medicine

    Background:

    • Endotracheal administration is a potential route for drug delivery.
    • Diazepam is a commonly used sedative and anxiolytic medication.

    Purpose of the Study:

    • To assess diazepam absorption via the endotracheal route in cats.
    • To evaluate pulmonary pathologic changes following endotracheal diazepam administration.

    Main Methods:

    • Six cats received endotracheal diazepam; five received saline as a control.
    • Serial blood gases and serum diazepam levels were monitored for 90 minutes.
    • Pulmonary tissues were examined histologically after 48 hours.

    Main Results:

    • Diazepam levels peaked at 2 minutes and remained therapeutic for 90 minutes.

    Related Experiment Videos

  • No significant changes in blood gases (pH, PO2, PCO2) were observed.
  • A higher incidence of pneumonitis was found in the diazepam group compared to the saline group.

    • Conclusions:

    • Endotracheal diazepam is well-absorbed but induces lung inflammation.
    • Adverse pulmonary effects may limit the clinical use of endotracheal diazepam.