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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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Immunogenic Cell Stress and Death Sensitize Tumors to Immunotherapy

Oliver Kepp1,2, Guido Kroemer1,2,3

  • 1Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, 75006 Paris, France.

Cells
|December 22, 2023
PubMed

Insights

Malignant cell plasticity drives resistance to chemotherapy and targeted therapies, limiting treatment effectiveness. Understanding this adaptability is key to overcoming therapeutic challenges in cancer.

Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Chemotherapy and targeted therapies are mainstays of cancer treatment.
  • Malignant cell plasticity is a significant challenge, leading to treatment resistance.
  • Developing resistance limits the long-term efficacy of current cancer interventions.

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