Related Experiment Video

Updated: Aug 23, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

[Evaluation of the bronchial provocation test with histamine in asthmatic children]

C Vázquez Cordero, M J Azcárate, M Salazar

    Anales Espanoles De Pediatria
    |November 1, 1986
    PubMed

    Insights

    Histamine inhalation challenge effectively diagnoses asthma and assesses severity in children. A threshold of less than 8 mg/ml for bronchial hyperreactivity may require careful interpretation based on population and method.

    Area of Science:

    • Pediatric Pulmonology
    • Respiratory Medicine
    • Clinical Allergy

    Context:

    • Asthma diagnosis and severity assessment in children are critical.
    • Histamine inhalation challenge is a standard method for evaluating bronchial hyperreactivity.
    • Understanding population-specific responses is key to accurate interpretation.

    Purpose:

    • To evaluate the utility of histamine inhalation challenge in diagnosing and assessing asthma severity in children.
    • To compare bronchial hyperreactivity in asthmatic children, control children, and control adults.
    • To determine the reliability of specific thresholds for bronchial hyperreactivity across different groups.

    Summary:

    • Histamine inhalation challenge was conducted on 32 asthmatic children, 20 control children, and 16 control adults.
    • The concentration of histamine causing a 20% fall in FEV1 (PC20FEV1) was measured.
    • Control adults showed no values below 8 mg/ml, while 35% of control children had values between 4-8 mg/ml. Asthmatic children on intermittent medication had higher PC20FEV1 than those on daily medication, with 2 mg/ml distinguishing these groups. The test demonstrated high reproducibility.
    • A PC20FEV1 value below 8 mg/ml may not always reliably indicate bronchial hyperreactivity, depending on the methodology and population studied.

    Impact:

    • Provides evidence for the diagnostic and prognostic value of histamine challenge in pediatric asthma.
    • Highlights the need for population-specific interpretation of bronchial hyperreactivity thresholds.
    • Informs clinical practice regarding the use and interpretation of histamine inhalation challenge in pediatric populations.

    More Related Videos

    Murine Model of Allergen Induced Asthma08:05

    Murine Model of Allergen Induced Asthma

    Published on: May 14, 2012

    Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

    Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

    Published on: March 3, 2023

    Related Concept Videos

    Asthma: Pathogenesis and Management01:20

    Asthma: Pathogenesis and Management

    Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
    Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
    Asthma-I: Introduction01:29

    Asthma-I: Introduction

    Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
    Asthma-II: Pathophysiology and Classification01:26

    Asthma-II: Pathophysiology and Classification

    Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
    Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
    Critical processes in asthma pathophysiology include:
    Asthma-IV: Diagnostic and Management01:30

    Asthma-IV: Diagnostic and Management

    The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
    Clinical Assessment for Asthma:
    This is the first step in diagnosing and managing asthma. It includes:
    Asthma I: Introduction01:28

    Asthma I: Introduction

    Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
    Asthma III: Clinical Manifestations01:13

    Asthma III: Clinical Manifestations

    Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...