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Evolution of Systemic Therapy in Medulloblastoma Including Irradiation-Sparing Approaches
Naureen Mushtaq1, Rahat Ul Ain2, Syed Ahmer Hamid3
1Division of Pediatric Oncology, Department of Oncology, Aga Khan University, Karachi 74800, Pakistan.
Abstract:
The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review.
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