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Related Concept Videos

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Jul 7, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study.

Antonio Gidaro1, Alessandro Palmerio Delitala2, Roberto Manetti2

  • 1Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Via G.B. Grassi N° 74, 20157 Milan, Italy.

Hematology Reports
|December 22, 2023
PubMed
Summary
This summary is machine-generated.

Platelet microvesicles (MVs) correlate with cardiovascular risk factors in healthy adults. This study suggests MVs may have a future role in screening exams for cardiovascular health.

Keywords:
C-reactive protein (CRP)Interleukin 10 (IL-10)Interleukin 17 (IL-17)Interleukin 6 (IL-6)Protein Sfactor VII (FVII)fibrinogenhomocysteinemicroparticlesmicrovesiclesplasminogen activator inhibitor-1 (PAI-1)thrombin activatable fibrinolysis inhibitor (TAFI)transforming growth factor β (TGF-β)von Willebrand factor (VWF)

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Area of Science:

  • Cardiovascular Research
  • Hematology
  • Immunology

Background:

  • Platelet microvesicles (MVs) are implicated in blood coagulation and inflammation.
  • Understanding MV relationships with cardiovascular risk factors is crucial for healthy aging.

Purpose of the Study:

  • To investigate the association between platelet microvesicles (MVs) and various markers of inflammation, coagulation, and fibrinolysis in healthy individuals.
  • To determine if MVs correlate with age and established cardiovascular risk factors.

Main Methods:

  • Prospective enrollment of healthy volunteers over 18 years old.
  • Measurement of MVs and plasma levels of inflammatory markers (CRP, IL-6, IL-10, IL-17, TGF-β), coagulation factors (fibrinogen, PAI-1, VWF, FVII, homocysteine, TAFI, Protein S).

Main Results:

  • A total of 246 individuals were evaluated (median age 65).
  • MVs positively correlated with age and multiple cardiovascular risk markers including CRP, IL-6, IL-10, IL-17, TGF-β, fibrinogen, PAI-1, VWF, FVII, and homocysteine.
  • MVs inversely correlated with TAFI and Protein S; ROC analysis identified a potential MV cutoff value (700 kMP).

Conclusions:

  • This study provides the first comprehensive correlation of MVs with a wide array of cardiovascular risk factors in healthy individuals.
  • Platelet microvesicles show potential as a novel biomarker for cardiovascular risk assessment and screening.