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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Genetics in Ischemic Stroke: Current Perspectives and Future Directions.

Ka Zhang1, Shaun S E Loong2,3, Linus Z H Yuen3

  • 1Division of Neurology, Department of Medicine, National University Hospital, Singapore 119074, Singapore.

Journal of Cardiovascular Development and Disease
|December 22, 2023
PubMed
Summary

Genetics influences ischemic stroke risk, treatment response, and recovery. This review explores recent genetic findings and their clinical applications for personalized stroke medicine and new therapies.

Keywords:
geneticsgenome-wide association studies (GWASs)ischemic strokepharmacogeneticspharmacogenomicsstroke recovery

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Area of Science:

  • Neurology
  • Genetics
  • Stroke Medicine

Background:

  • Ischemic stroke is a complex condition with both genetic and environmental influences.
  • Recent research increasingly focuses on the genetic underpinnings of stroke risk, treatment efficacy, and functional recovery.
  • Understanding these genetic factors is crucial for advancing stroke care.

Purpose of the Study:

  • To review recent findings from genetic studies on ischemic stroke.
  • To explore the role of genetics in stroke occurrence, treatment response, and recovery.
  • To discuss the clinical applications of genetic insights in personalized medicine and therapeutic development.

Main Methods:

  • Literature review of recent genetic studies related to ischemic stroke.
  • Analysis of findings concerning genetic influence on stroke risk, treatment, and recovery.
  • Synthesis of current knowledge on clinical applications of genetic insights.

Main Results:

  • Genetics plays a significant role in individual susceptibility to ischemic stroke.
  • Genetic variations impact how patients respond to stroke treatments.
  • Genetic factors influence the extent and effectiveness of post-stroke functional recovery.

Conclusions:

  • Genetic insights offer potential for improved stroke risk stratification.
  • Personalized therapeutic strategies can be guided by an individual's genetic profile.
  • Genetic research may reveal novel targets for future stroke therapies.