Multifunctional Core/Shell Diamond Nanoparticles Combining Unique Thermal and Light Properties for Future Biological...

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Development of multifunctional nanoparticles for theranostics is crucial for advanced medical applications.
• Diamond nanoparticles offer unique optical and thermal properties suitable for biomedical applications.

Purpose of the Study:

• To engineer core/shell chemical vapor deposition diamond nanoparticles.
• To enable local photoinduced hyperthermia, thermometry, and fluorescent imaging.
• To investigate the temperature-dependent optical properties of silicon-vacancy color centers in diamond.

Main Methods:

• Fabrication of boron-doped diamond core/shell nanoparticles via chemical vapor deposition.
• Embedding silicon-vacancy (SiV) color centers in the diamond shell.
• Utilizing laser irradiation to induce photo-thermal effects and monitoring spectral shifts of SiV zero-phonon lines for thermometry.

Main Results:

• Demonstrated precise temperature control of nanoparticles via incident laser power.
• Achieved hyperthermia-level temperatures at biologically safe laser power levels.
• SiV color centers provided intense, narrowband fluorescence for imaging and temperature sensing.

Conclusions:

• Multifunctional diamond nanoparticles are effective for localized hyperthermia and nanothermometry.
• The SiV color centers facilitate simultaneous fluorescent imaging and temperature monitoring.
• These nanoparticles present a promising platform for targeted cancer therapy and diagnostics.