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Exogenous Klotho Extends Survival in COVID-19 Model Mice
Farhang Alem1, Natalia Campos-Obando2, Aarthi Narayanan1
1Biomedical Research Laboratory, George Mason University, 4400 University Dr., Fairfax, VA 22030, USA.
Pathogens (Basel, Switzerland)
|December 22, 2023
Summary
Klotho, an anti-aging protein, improved survival in COVID-19 model mice. This suggests Klotho may be a therapeutic target for severe COVID-19, warranting further research into its role in disease pathogenesis and aging.
Area of Science:
- Gerontology
- Virology
- Immunology
Background:
- COVID-19 severity is linked to aging risk factors.
- Low serum Klotho levels correlate with severe COVID-19 manifestations.
- Klotho is an anti-aging protein with potential relevance to COVID-19.
Purpose of the Study:
- To investigate the therapeutic potential of exogenous Klotho in a COVID-19 mouse model.
- To assess the impact of Klotho supplementation on survival rates in SARS-CoV-2 infected mice.
Main Methods:
- Administration of exogenous Klotho to COVID-19 model mice.
- Statistical analysis of survival data using parametric and non-parametric models.
Main Results:
- Klotho supplementation demonstrated a statistically significant survival benefit.
- The protective effect was observed across different statistical models.
Conclusions:
- Exogenous Klotho shows promise as a therapeutic intervention for severe COVID-19.
- Further research is needed to understand Klotho's mechanism in COVID-19 and its interaction with biological aging.
