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The Intersection between Pharmacogenomics and Health Equity: A Case Example.

Courtney Paetznick¹, Olihe Okoro²

¹Children's Minnesota, Minneapolis, MN 55404, USA.

Pharmacy (Basel, Switzerland)

|December 22, 2023

Summary

Pharmacogenomics (PGx) and precision medicine can either improve or worsen health equity. Understanding the medication experience is key to ensuring equitable healthcare for all populations.

Keywords:

health disparities health equity pharmacogenomics

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Area of Science:

Pharmacogenomics
Precision Medicine
Health Equity

Background:

Pharmacogenomics (PGx) and precision medicine hold significant potential to impact health equity.
The integration of PGx into healthcare may either advance or exacerbate existing health disparities.
The medication experience is a critical factor at the intersection of PGx, precision medicine, and health equity.

Purpose of the Study:

To analyze the dual potential of pharmacogenomics to promote or hinder health equity.
To examine the role of the medication experience in the context of pharmacogenomics and health disparities.
To provide recommendations for researchers and clinicians to foster equitable PGx implementation.

Main Methods:

Case study analysis to illustrate the complexities of pharmacogenomics in clinical practice.
Literature review on the intersection of pharmacogenomics, precision medicine, and health equity.
Synthesis of perspectives to formulate actionable recommendations.

Main Results:

Pharmacogenomics presents a complex interplay with health equity, offering both opportunities for advancement and risks of widening disparities.
The individual and population-level medication experience is central to understanding and addressing these impacts.
Case examples highlight the practical implications of PGx in diverse patient populations.

Conclusions:

Equitable integration of pharmacogenomics requires careful consideration of the medication experience.
Recommendations are proposed for the research and clinical communities to promote health equity in precision medicine.
Proactive strategies are necessary to ensure pharmacogenomics benefits all individuals and populations.