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Hemodiafiltration using readily available equipment.

W Kohnle, K Sprenger, B Spohn

    Journal of Dialysis
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    This study demonstrates hemodiafiltration using standard dialysis equipment, reducing treatment time. The method efficiently clears urea, creatinine, and middle molecules like B2 microglobulin.

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    Area of Science:

    • Nephrology
    • Biomedical Engineering

    Background:

    • Hemodiafiltration combines hemodialysis and hemofiltration for blood purification.
    • It clears low molecular substances via diffusion and middle molecules via convection.

    Purpose of the Study:

    • To demonstrate hemodiafiltration using readily available equipment.
    • To assess the efficacy and efficiency of this adapted procedure.

    Main Methods:

    • Utilized a regular dialysis machine, an "open membrane," and the COTRAL device.
    • Evaluated clearance rates for urea, creatinine, and inulin at varying blood and dialysate flow rates.
    • Measured substance extraction over a 3.5-hour treatment period.

    Main Results:

    • Achieved significant clearance values for urea (up to 192 ml/min), creatinine (up to 161 ml/min), and inulin (up to 91 ml/min).
    • Demonstrated efficient removal of urea (92.4g), creatinine (6.3g), and B2 microglobulin (36mg) within 3.5 hours.
    • Treatment time was reduced to approximately two-thirds of standard dialysis duration.

    Conclusions:

    • Hemodiafiltration can be effectively performed with accessible equipment.
    • The procedure shows promise for efficient blood purification and reduced treatment times, warranting further investigation.