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Updated: Jul 7, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
435
P4HA1 expression and function in esophageal squamous cell carcinoma.
Wenbin Gou1, Beiwen Song2, Yongqiang Yang2
1Department of Pathology, People's Hospital of Wanning, Wanning, Hainan Province, China.
Medicine
|December 22, 2023
Summary
Prolyl 4-hydroxylase subunit α1 (P4HA1) is highly expressed in esophageal squamous cell carcinoma and is an independent prognostic factor for overall and progression-free survival. P4HA1 may serve as a biomarker for early diagnosis and targeted therapy.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Esophageal squamous cell carcinoma (ESCC) poses a significant global health challenge.
- Identifying reliable biomarkers for ESCC prognosis and targeted therapy is crucial.
Purpose of the Study:
- To investigate the expression of prolyl 4-hydroxylase subunit α1 (P4HA1) in ESCC.
- To determine the association between P4HA1 expression and clinicopathological features.
- To evaluate the prognostic value of P4HA1 in ESCC patients.
Main Methods:
- Utilized The Cancer Genome Atlas and Genotype-Tissue Expression databases for P4HA1 expression data.
- Performed immunohistochemistry to assess P4HA1 protein levels in tumor and adjacent tissues.
- Analyzed the relationship between P4HA1 expression and clinicopathological parameters using χ2 test.
- Conducted univariate and multivariate survival analyses (overall survival and progression-free survival).
Main Results:
- P4HA1 mRNA expression was higher in esophageal cancer tissues compared to normal tissues.
- Immunohistochemistry revealed high P4HA1 expression in ESCC tissues (68.7%) versus negative expression in paracancerous tissues.
- P4HA1 expression correlated significantly with tumor differentiation, site, lymph node metastasis, and TNM stage.
- P4HA1 expression was identified as an independent prognostic factor for both overall survival and progression-free survival in ESCC patients.
Conclusions:
- P4HA1 is significantly upregulated in esophageal squamous cell carcinoma.
- P4HA1 expression is a critical independent predictor of patient survival.
- P4HA1 represents a potential novel biomarker for early diagnosis, prognosis, and targeted therapy in ESCC.
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