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Hemodynamics during hemodialysis, sequential ultrafiltration and hemofiltration.

H Hampl, H Paeprer, V Unger

    Journal of Dialysis
    |January 1, 1979
    PubMed
    Summary

    Conventional hemodialysis causes unstable circulation and hypotension. Hemofiltration and sequential ultrafiltration better maintain circulatory stability and blood pressure in patients undergoing dialysis.

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    Area of Science:

    • Nephrology
    • Cardiovascular Physiology

    Background:

    • Patients on maintenance hemodialysis often experience circulatory disturbances.
    • Hemodialysis involves fluid and solute removal, impacting cardiovascular function.

    Purpose of the Study:

    • To compare circulatory parameter changes during conventional hemodialysis, sequential ultrafiltration, and hemofiltration.
    • To assess the impact of different dialysis modalities on hemodynamic stability.

    Main Methods:

    • Cardiac catheterization was used to measure circulatory parameters.
    • Patients were divided into three groups: conventional hemodialysis, sequential ultrafiltration, and hemofiltration.

    Main Results:

    • All groups showed reduced cardiac output, stroke volume, pulmonary artery pressure, and plasma volume.

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  • Hemodialysis led to unstable hemodynamics, including hypotension and increased heart rate.
  • Hemofiltration and sequential ultrafiltration maintained stable blood pressure and heart rate, with increased peripheral vascular resistance.

    • Conclusions:

    • Hemofiltration and sequential ultrafiltration offer better hemodynamic stability compared to conventional hemodialysis.
    • These methods preserve the patient's vasoconstrictive counterregulation ability during dialysis.