Defining repetitive behaviours in frontotemporal dementia

Area of Science:

• Neuroscience
• Behavioral Science

Background:

• Repetitive behaviors are prevalent in frontotemporal dementia (FTD), encompassing compulsivity, hoarding, and insistence on sameness.
• Current classification of these behaviors in FTD is inconsistent, hindering research and clinical understanding.
• Heterogeneous terminology and lack of precise definitions impede differentiation of pathological behaviors and understanding of underlying mechanisms.

Approach:

• This review synthesizes established definitions of repetitive behaviors from other neuropsychiatric disorders.
• It proposes operational definitions tailored for FTD patients.
• The review explores neurocognitive bases and habit formation contributing to FTD repetitive behaviors, referencing non-human models and FTD social behavior studies.

Key Points:

• Repetitive behaviors in FTD lack a harmonized classification system.
• Operational definitions are proposed for FTD-specific repetitive behaviors.
• Neurocognitive underpinnings and habit formation are explored as perpetuating factors.
• Therapeutic approaches for distinct repetitive behaviors are highlighted.

Conclusions:

• Standardized definitions are crucial for differentiating FTD repetitive behaviors and understanding their mechanisms.
• Proposed definitions and therapeutic strategies aim to improve classification, measurement, and treatment of these symptoms.
• Addressing repetitive behaviors is vital for enhancing the quality of life in FTD patients.