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Updated: Jul 7, 2025
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
Time-effectiveness of low-frequency rTMS for epilepsy and improvement in cognitive function in patients: A systematic
Zheng Wang1, Xiaoying Zhang1, Gesang Meiduo1
1Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310013, China.
Objective:
Performed a systematic review and meta-analysis to evaluate the effect of low-frequency repeated transcranial magnetic stimulation (rTMS) in treating epilepsy.
Methods:
An electronic search of PubMed, EMBASE, Weipu, and Wanfang databases was conducted to select randomized controlled clinical trials (RCTs) of low-frequency rTMS for epilepsy and related diseases. Outcome measures mainly included seizure frequency, response rate, and cognitive assessment score. Odds ratio (OR), standardized mean difference (SMD), and 95% confidence interval (CI) were calculated to evaluate these effects. The heterogeneity test was measured using chi-square and I2. Possible effects of covariates were investigated using meta-regressions. The sensitivity analysis and publication bias assessment also was performed.
Results:
The retrieval time was from the establishment to February 2023. 18 RCTs were identified, including 1224 patients. The results showed that rTMS treatment reduced the frequency of the seizure in antiepileptics drugs (AEDs) therapy (SMD = -1.066, 95% CI [-1.618, -0.515]), especially in the first week after treatment (SMD = -1.641, 95% CI [-2.778, -0.503]), and significantly improved the effective rate (OR = 3.877, 95% CI [2.725, 5.515]) and cognitive assessment score (SMD = 1.038, 95% CI [0.745, 1.332]). The sensitivity analysis indicated that the results were stable, and Egger's tests showed no evidence of publication biases.
Conclusion:
The current evidence suggests that low-frequency rTMS-assisted therapy significantly improves antiepileptics drugs' efficacy and improves patients' cognitive function. This additional therapeutic effect has a certain timeliness. Limited by the quantity and quality of the selected studies, further prospective studies with more participants are needed to draw broad and accurate conclusions.
