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The case of the missing Ks: Base editor screen to assess cellular fitness at single lysines
Varun Gopala Krishna1, Verena Gudrun Gautsch1, Vincenzo D'Angiolella1
1MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.
Molecular Cell
|December 22, 2023
Abstract:
In this issue of Molecular Cell, Bao et al.1 set out to elucidate "functional lysines" in the genome using adenine base editors. The study reveals several cases of alteration of functions that previous canonical CRISPR-Cas9 screens were unable to detect.
