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Cell transport in model extracellular matrices.

W D Comper, L Pratt, C J Handley

    Archives of Biochemistry and Biophysics
    |January 1, 1987
    PubMed
    Summary
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    Ordered countercurrent convection, driven by extracellular matrix components, rapidly transports cells and particles. This nonspecific cell transport mechanism may play a role in vivo during tissue remodeling and embryogenesis.

    Area of Science:

    • Biophysics
    • Cell Biology
    • Biomaterials

    Background:

    • Cellular transport is crucial for biological processes.
    • Extracellular matrix (ECM) components influence cell behavior.
    • Understanding cell movement mechanisms is vital for developmental biology and tissue engineering.

    Purpose of the Study:

    • To investigate the phenomenon of ordered countercurrent convection for cell transport.
    • To determine the factors influencing the rate and specificity of this transport.
    • To explore the potential in vivo relevance of this transport mechanism.

    Main Methods:

    • Creation of convection currents using macromolecular mixtures and their degradation products.
    • Observation and measurement of cell and particle movement in controlled isothermal systems.

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  • Experiments conducted in open systems and confined spaces (e.g., microfluidic tubes).

    • Main Results:

    • Ordered countercurrent convection was established, creating structured flows.
    • Rapid, nonspecific transport of various cell types and inert particles (1-100 mm/h) was observed.
    • Transport occurred in confined spaces and over extended distances, demonstrating robustness.

    Conclusions:

    • Structured flows driven by ECM-related convection can rapidly transport cells.
    • The nonspecific nature suggests a fundamental biophysical transport mechanism.
    • This convection-driven transport may contribute to cell movement in vivo during embryogenesis and tissue remodeling.