[Inhibitory effect of human plasma on 17-1A-dependent cellular cytotoxicity]

Mouse monoclonal antibody 17-1A-dependent cellular cytotoxicity hardly revealed any killer activity in the presence of human plasma, nor did 17-1A show complement-dependent cytotoxicity. ADCC of 17-1A-armed effector cells was also inhibited by human plasma. These results were caused by the inhibition of 17-1A binding to the Fc receptors of effector cells.