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Updated: Jul 7, 2025
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Isolation and Culture of Endothelial Cells from the Embryonic Forebrain
Published on: January 23, 2014
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Interactions between neural cells and blood vessels in central nervous system development
Keiko Morimoto1, Hidenori Tabata1,2, Rikuo Takahashi1
1Department of Anatomy, Keio University School of Medicine, Tokyo, Japan.
Summary
Neural cells and blood vessels have a complex, bidirectional relationship crucial for central nervous system (CNS) development. This review explores their interactions and implications for neurodevelopmental disorders.
Area of Science:
- Neuroscience
- Developmental Biology
- Vascular Biology
Background:
- The central nervous system (CNS) relies on intricate interactions between neural cells and blood vessels for proper function.
- Neurons, glial cells, and neural progenitors actively participate in blood vessel formation, which in turn serves as a scaffold for cell migration.
Conclusions:
- The dynamic interaction between neural and vascular systems is fundamental to CNS development.
- Dysregulation of this neurovascular crosstalk may contribute to the pathogenesis of neurodevelopmental disorders.
Keywords:
astrocyteblood vessel formationblood vessel-guided migrationinterneuronmicroglianeural progenitoroligodendrocyteMore Related Videos
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