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Atherosclerosis III: Management01:26

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Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development.

Linnea Tscheuschner1, Abraham R Tzafriri2

  • 1Department of Vascular Surgery, National and Kapodistrian University of Athens, 15772 Athens, Greece.

Bioengineering (Basel, Switzerland)
|December 23, 2023
PubMed
Summary

Tissue engineering advances cardiovascular research by creating disease models for studying disease progression and testing treatments. These models require specific cellular, mechanical, and structural properties for accurate simulation and drug development.

Keywords:
atherosclerosisdisease modelsdrug-coated balloonsdrug-eluting stentsnanoparticlestissue engineering

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Regenerative Medicine

Background:

  • Tissue engineering initially focused on replacing diseased organs.
  • A significant need exists for disease models to study progression and test treatments.
  • Tissue engineering offers controllable translational disease models.

Purpose of the Study:

  • Review uses of tissue-engineered disease models in cardiovascular research.
  • Provide guidelines for creating adequate disease models.
  • Support development of drug-delivery therapies using these models.

Main Methods:

  • Discuss requirements for disease models.
  • Address testing of drugs, nanoparticles, and drug-eluting devices.
  • Consider cellular composition, mechanical, and structural properties.

Main Results:

  • Tissue-engineered models can simulate pathological realities.
  • Guidelines are proposed for model generation.
  • Models are valuable for drug and device testing.

Conclusions:

  • Tissue-engineered disease models are crucial for cardiovascular research.
  • Accurate simulation requires attention to cellular, mechanical, and structural aspects.
  • These models facilitate disease mechanism study and therapeutic development.